Contact UsConsumer Site
Product
Technology
Clinical Data
Prescribing
Refer
twiist™ is designed
to help give patients tighter glucose control
Learn how the twiist AID System powered by Tidepool can help your patients better manage their type 1 diabetes (T1D).
Sign up to watch a twiist webinar!
Sign Up Now
Learn how the twiist™ AID System powered by Tidepool can help your patients better manage their type 1 diabetes (T1D).
Sign up to watch a twiist webinar!
Sign Up Now

twiist has further personalized T1D care by offering your patients advanced technology with the precision and flexibility to adapt to their day.1-7

Learn more about twiist through this informational, prerecorded webinar, and hear how you can empower your patients.
Greater Personalized Control
From retroactive carb entry capabilities and 3 bolusing options to a 300 unit capacity and the widest glucose target range available (87-180 mg/dL)1,3-7 each feature is designed to help provide tighter glucose control by letting patients adapt settings to their daily needs.
Advanced Technology
twiist can help reduce the risk of unexplained hyperglycemia by detecting occlusions faster, so patients can take action sooner.2* By using iiSure™ sound wave technology, it detects occlusions up to 9x faster than other AID systems.2
Simplified Access
Most patients will pay $0 for the first month and no more than $50 per month after that, making cost less of a prescribing barrier.†
*Klonoff DC, et al. Time to Moderate and Severe Hyperglycemia and Ketonemia Following an Insulin Pump Occlusion. J Diabetes Sci Technol 2024.
†The twiist™ Savings Program is available to individuals with a valid prescription and commercial insurance that covers twiist. Eligible participants can receive a Starter Kit for $0 and pay no more than $50 for Refill Kits. This offer is not valid for individuals enrolled in Medicare, Medicaid, or any other federal or state programs, or for cash-paying patients and non-covered claims. It is available only in the U.S. and is not valid in Puerto Rico, U.S. Territories, or where prohibited by law. While most commercially insured participants qualify for the $50 Refill Kit offer, those with high-deductible plans who haven't met their deductible may pay more than $50 per Refill Kit until their deductible is met. The maximum benefit is $200 per Refill Kit for covered claims. Terms are subject to change. Call us at 1-877-489-4478 or contact your insurance provider to confirm coverage.
Sign up and watch the twiist webinar recording to learn more

Please complete the form below for instant access to this informative, prerecorded webinar.

Are you a person with diabetes? Learn how you can get started with twiist.

*All fields with an asterisk (*) and check box are required.

Specialty*
By clicking the “Submit” button, you confirm that you have read, understood, and agree to be bound by Sequel Med Tech’s Terms of Use and that you have read and acknowledged Sequel Med Tech’s Privacy Policy. These Terms of Use govern your access to and use of our services, including any content, functionality, and services offered on or through our sites. If you do not agree to these terms, you must not access or use the platform.
Thank you! Your submission has been received!
Oops! Something went wrong while submitting the form.
Personalized Diabetes Control
Product
Product Overview
Technology
Loop AlgorithmiiSure technology
Clinical Data
Study DataResources
Prescribing
Prescribing twiist
Get Started
Contact Us
INDICATIONS FOR USE1
The twiist system is intended for the subcutaneous delivery of insulin, at set and variable rates, for the management of diabetes mellitus in persons requiring insulin, ages six and above. The pump is able to reliably and securely communicate with compatible, digitally connected devices, including automated insulin dosing software, to receive, execute, and confirm commands from these devices. The twiist system is intended for single patient, home use and requires a prescription. 

The twiist Loop algorithm, is intended for use with compatible integrated continuous glucose monitors (iCGM) and the twiist alternate controller enabled (ACE) insulin infusion pump to automatically increase, decrease, and suspend delivery of basal insulin based on iCGM readings and predicted glucose values. It can also recommend, and with the user’s confirmation, deliver correction boluses when glucose values are predicted to exceed user configurable thresholds. The twiist Loop algorithm is intended for the management of type 1 diabetes mellitus in persons six years of age and greater, and is intended for single-patient use.The twiist automated insulin delivery system  is for prescription use only . 

The twiist automated insulin delivery system simple bolus calculator, available when Loop is off, is indicated for use for aiding the user in determining the bolus insulin dosage for management of diabetes mellitus based on consumed carbohydrates, operator-entered blood glucose, insulin sensitivity,  carbohydrate ratio, correction range, and current active insulin.
REFERENCES

1. The twiist Automated Insulin Delivery (AID)System Powered by Tidepool User Guide, Sequel Med Tech: DKPI-09233-001-EN 1.72024-10-21
2. Calculation based on a comparison of the following IFUs. The following reported 1 U/hr basal rate: The twiist Automated Insulin Delivery (AID) System Powered by Tidepool User Guide, Sequel Med Tech(DKPI-09233-001-EN 1.7 2024-10-21). Omnipod 5 Technical User Guide (PT-000941-AW Rev07 10/24), MiniMed 780G System User Guide (M036461C001_22023-02-24). iLet Bionic Pancreas System User Guide (LA000081_E 3-19-24). The following reported 2 U/hr basal rate: t:slim X2 Insulin Pump User Guide (AW-1011648_B 2023-Nov-09), Tandem Mobi System User Guide (AW-1012691_A2023-Dec-07.)
3. Omnipod 5 Technical User Guide. Insulet Corporation; PT-000941-AW Rev. 07 10/24
4. MiniMed 780G with the Guardian. Sensor System User Guide, Medtronic: M036461C001_2 2023-02-24.
5. iLet Bionic Pancreas System Quick Reference Guide, Beta Bionics: LA000082_E.
6. t:slim X2 Insulin Pump with Control-IQ Technology User Guide, Tandem Diabetes Care: AW-1011648_B 2023-Nov-09.
7. Tandem Mobi System, Tandem Diabetes Care: AW-1012691_A 2023-Dec-07.
8. Lum JW, Bailey RJ, Barnes-Lomen V, et al. A real-world prospective study of the safety and effectiveness of the Loop open source automated insulin delivery system. Diabetes Technol Ther. 2021;23(5):367-375.
9. Wong JJ, et al. Psychosocial Effects of the Loop Open-Source Automated Insulin Delivery System. J Diabetes Sci Technol 2023;17:1440–7.
10. R. D. Butterfield and N. M. Sims, “Performance of a Continuous Subcutaneous Insulin Infusion (CSII) Pump with Acoustic Volume and Flow Sensing in Simulated High Consequence Situations,” in IEEE Open Journal of Engineering in Medicine and Biology, doi: 10.1109/OJEMB.2024.3408092.

Product not yet available outside of the U.S.
CONTRAINDICATIONS

The twiist automated insulin delivery system is not intended for anyone unable or unwilling to:

  • Test blood glucose (BG) levels as recommended by their healthcare provider.
  • Maintain sufficient diabetes selfcare skills.
  • See their healthcare provider regularly.
  • Demonstrate adequate carbohydrate-counting skills (preferred, not required).

The user must not:

  • Have difficulty seeing.
  • Have difficulty hearing.
  • Have deficient cognitive capabilities.
  • Have physical impairments that would make operating the pump or iPhone difficult.
For full FreeStyle Libre 3 Plus sensor safety information, please visit https://www.freestyle.abbott/us-en/safety-information.html.
The sensor housing, FreeStyle, Libre, and related brand marks are marks of Abbott and used with permission.

“twiist,” “iiSure,” and the twiist logo are licensed trademarks of Sequel Med Tech, LLC. “Tidepool” and the Tidepool logo are trademarks of Tidepool Project, a fully-qualified 501(c)(3) nonprofit organization.
© 2026 Sequel Med Tech, LLC. All rights reserved.
‍Privacy Policy  |  Consumer Health Data Privacy Policy  |  Terms of Use  ‍|  Safety Information  |  Cookie Settings