Introducing a breakthrough

The next era in diabetes care is about to begin with the twiist™ AID System

Be among the first to experience twiist

The twiist Automated Insulin Delivery (AID) System will be available soon in the United States. Enter your information below and select your preferred date and time to reserve a spot for the twiist webinar.

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twiist will be the first and only commercially available Automated Insulin Delivery (AID) System powered by Tidepool Loop—designed by and for people with diabetes.1

Discover what makes the twiist AID System different

What is twiist?

Integrating twiist into your patients’ lives couldn’t be easier:

• Local pharmacy pick up
• 24/7 product support
• No long-term contracts

Personalized Control

Widest glucose target range

From 87 mg/dL—the lowest of any available AID system—to 180 mg/dL twiist supports greater personalization and tighter control1-6

Multiple discreet bolus options

Bolus through the iPhone®, Apple Watch®*, and using the on-device bolus button1

Flexible wear options

Large enough to hold up to 300 units, small enough to be discreet (<2 oz)1

*Apple Watch app-based control is optional.

Advanced Technology

Precise measurement for accurate delivery

twiist directly measures the volume of insulin delivered with every micro-dose, with four checkpoints to ensure accurate delivery1

Fastest occlusion detection

twiist alerts users to blockages up to 9 times faster than other AID systems1-6†

Precise measurement for accurate delivery

in severe hypoglycemia, A1C, and time in range1,7‡

Fastest occlusion detection

outcomes associated with the use of DIY Loop1

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INDICATIONS FOR USE1

The twiist system is intended for the subcutaneous delivery of insulin, at set and variable rates, for the management of diabetes mellitus in persons requiring insulin, ages six and above. The pump is able to reliably and securely communicate with compatible, digitally connected devices, including automated insulin dosing software, to receive, execute, and confirm commands from these devices. The twiist system is intended for single patient, home use and requires a prescription. 

The twiist Loop algorithm, is intended for use with compatible integrated continuous glucose monitors (iCGM) and the twiist alternate controller enabled (ACE) insulin infusion pump to automatically increase, decrease, and suspend delivery of basal insulin based on iCGM readings and predicted glucose values. It can also recommend, and with the user’s confirmation, deliver correction boluses when glucose values are predicted to exceed user configurable thresholds. The twiist Loop algorithm is intended for the management of type 1 diabetes mellitus in persons six years of age and greater, and is intended for single-patient use.The twiist automated insulin delivery system  is for prescription use only . 

The twiist automated insulin delivery system simple bolus calculator, available when Loop is off, is indicated for use for aiding the user in determining the bolus insulin dosage for management of diabetes mellitus based on consumed carbohydrates, operator-entered blood glucose, insulin sensitivity,  carbohydrate ratio, correction range, and current active insulin.
REFERENCES

1. The twiist Automated Insulin Delivery (AID)System Powered by Tidepool User Guide, Sequel Med Tech: DKPI-09233-001-EN 1.72024-10-21
2. Calculation based on a comparison of the following IFUs. The following reported 1 U/hr basal rate: The twiist Automated Insulin Delivery (AID) System Powered by Tidepool User Guide, Sequel Med Tech(DKPI-09233-001-EN 1.7 2024-10-21). Omnipod 5 Technical User Guide (PT-000941-AW Rev07 10/24), MiniMed 780G System User Guide (M036461C001_22023-02-24). iLet Bionic Pancreas System User Guide (LA000081_E 3-19-24). The following reported 2 U/hr basal rate: t:slim X2 Insulin Pump User Guide (AW-1011648_B 2023-Nov-09), Tandem Mobi System User Guide (AW-1012691_A2023-Dec-07.)
3. Omnipod 5 Technical User Guide. Insulet Corporation; PT-000941-AW Rev. 07 10/24
4. MiniMed 780G with the Guardian. Sensor System User Guide, Medtronic: M036461C001_2 2023-02-24.
5. iLet Bionic Pancreas System Quick Reference Guide, Beta Bionics: LA000082_E.
6. t:slim X2 Insulin Pump with Control-IQ Technology User Guide, Tandem Diabetes Care: AW-1011648_B 2023-Nov-09.
7. Tandem Mobi System, Tandem Diabetes Care: AW-1012691_A 2023-Dec-07.
8. Lum JW, Bailey RJ, Barnes-Lomen V, et al. A real-world prospective study of the safety and effectiveness of the Loop open source automated insulin delivery system. Diabetes Technol Ther. 2021;23(5):367-375.
9. Wong JJ, et al. Psychosocial Effects of the Loop Open-Source Automated Insulin Delivery System. J Diabetes Sci Technol 2023;17:1440–7.
10. R. D. Butterfield and N. M. Sims, “Performance of a Continuous Subcutaneous Insulin Infusion (CSII) Pump with Acoustic Volume and Flow Sensing in Simulated High Consequence Situations,” in IEEE Open Journal of Engineering in Medicine and Biology, doi: 10.1109/OJEMB.2024.3408092.

Product not yet available outside of the U.S.

CONTRAINDICATIONS

‍

The twiist automated insulin delivery system is not intended for anyone unable or unwilling to:

‍

  • Test blood glucose (BG) levels as recommended by their healthcare provider.
  • Maintain sufficient diabetes selfcare skills.
  • See their healthcare provider regularly.
  • Demonstrate adequate carbohydrate-counting skills (preferred, not required).

The user must not:

‍

  • Have difficulty seeing.
  • Have difficulty hearing.
  • Have deficient cognitive capabilities.
  • Have physical impairments that would make operating the pump or iPhone difficult.
For full FreeStyle Libre 3 Plus sensor safety information, please visit https://www.freestyle.abbott/us-en/safety-information.html.
The sensor housing, FreeStyle, Libre, and related brand marks are marks of Abbott and used with permission.

“twiist,” “iiSure,” and the twiist logo are licensed trademarks of Sequel Med Tech, LLC. “Tidepool” and the Tidepool logo are trademarks of Tidepool Project, a fully-qualified 501(c)(3) nonprofit organization.
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