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All the support you need to get the most from the twiist AID System
Whether you've just started out with the twiist™ Automated Insulin Delivery (AID) System or you've been with us for some time, we can help. Discover our twiist resources, created to ensure your journey is as successful as possible.
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Arecor announces Co-development Agreement with US Insulin Pump Device Company

Diabeloop and Sequel Med Tech Enter Partnership to Integrate FDA-Cleared DBLG2

Sequel Brings twiist™ Nationwide, Redefining Automated Insulin Delivery Category with Industry-First Innovation

El sistema twiist de administración automática de insulina (AAI) GUÍA DE USUARIO 1.15 ES-US

Sequel Statement Regarding Dean Kamen

New twiist Automated Insulin Delivery (AID) System User Guide 1.15

Staying in Control With the twiist AID System: How to Use the Workout Preset

Keeping Your twiist Pump Powered: Quick Guide to Charging twiist Batteries

Infusion Set Insertion Made Simple: The STICKS Method

Carb Entry With the twiist AID System: Insulin Delivery & Absorption Tips!

Sequel’s twiist™ Automated Insulin Delivery System Receives FDA 510(k) Clearance

Sequel Med Tech to Integrate twiist Automated Insulin Delivery (AID) System...

Sequel Med Tech and Senseonics Integrate Technologies...

Sequel Announces First CGM Integration for its twiist AID System

twiist Brochure

Managing Low Blood Sugar

Managing High Blood Sugar

Pre-Meal Preset

Workout Preset

twiist Pump Button

twiist AID System- iPhone and Pump Alert Settings

Travel With twiist

STICKS Method for Infusion Set Placement

Infusion Sets and Site Changes

How to Suspend and Resume Insulin Delivery

How to Deliver Mealtime Insulin

How to Change a Pump Battery

How to Change a Cassette

Carb Amount and Absorption Time

Get Help & Connect

We're here to support your twiist experience every step of the way. From setup to everyday use, our Customer Care Team is committed to providing you with the care you deserve.

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Day or night, our support team is just a call away. Whether you need a quick answer or step-by-step guidance, we’re ready to get you back to what matters most: living life on your terms.

Call us toll-free

(877) 4TW-IIST

(877) 489-4478

Education

Device-specific guides for twiist: setup, usage, troubleshooting, QRGs

Quick Reference Guides:

Carb Amount and Absorption Time

How to Deliver Mealtime Insulin

Travel With twiist

twiist Pump Button

How to Change a Cassette

How to Change a Pump Battery

How to Suspend and Resume Insulin Delivery

Infusion Sets and Site Changes

Pre-Meal Preset

STICKS Method for Infusion Set Placement

twiist AID System- iPhone and Pump Alert Settings

Workout Preset

BG Management Resources:

Managing High Blood Sugar

Managing Low Blood Sugar

Resource Videos

Carb Entry With the twiist AID System: Insulin Delivery & Absorption Tips!

Infusion Set Insertion Made Simple: The STICKS Method

Keeping Your twiist Pump Powered: Quick Guide to Charging twiist Batteries

Staying in Control With the twiist AID System: How to Use the Workout Preset

Updates & Additional Resources

Discover answers to top questions about twiist.

twiist Resources

New twiist Automated Insulin Delivery (AID) System User Guide 1.15

El sistema twiist de administración automática de insulina (AAI) GUÍA DE USUARIO 1.15 ES-US

twiist Brochure

Press Releases

Sequel Statement Regarding Dean Kamen

Sequel Brings twiist™ Nationwide, Redefining Automated Insulin Delivery Category with Industry-First Innovation

Diabeloop and Sequel Med Tech Enter Partnership to Integrate FDA-Cleared DBLG2

Arecor announces Co-development Agreement with US Insulin Pump Device Company

Sequel Med Tech to Integrate twiist Automated Insulin Delivery (AID) System...

Sequel Med Tech and Senseonics Integrate Technologies...

Sequel Announces First CGM Integration for its twiist AID System

Sequel’s twiist™ Automated Insulin Delivery System Receives FDA 510(k) Clearance

Community & Support

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Real-life user testimonials

The thing that I love most about twiist is how it reduces the mental load of living with diabetes for me. It is such a relief to be able to live life and not feel captive to my diabetes.

- Cheyne

My favorite thing about twiist is not having to take shots anymore.

- Macy (Age 6)

There are so many things I love about this pump. I have tried a lot of things but one of my favorite things being a mom to a child with type 1 is the glucose prediction feature because I look at her prediction before we go to bed at night and I can see if she is expected to be steady while she sleeps, which gives me some confidence that I can have a good night's sleep.

- Falyn

Put a new twiist on how you manage your type 1 diabetes.
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Frequently Asked Questions

Discover answers to top questions about twiist.

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Personalized Diabetes Control
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What is twiist™iiSure™ Technology
Apps & Software
twiist Loop
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INDICATIONS FOR USE
The twiist system is intended for the subcutaneous delivery of insulin, at set and variable rates, for the management of diabetes mellitus in persons requiring insulin, ages six and above. The pump is able to reliably and securely communicate with compatible, digitally connected devices, including automated insulin dosing software, to receive, execute, and confirm commands from these devices. The twiist system is intended for single patient, home use and requires a prescription.

The twiist Loop algorithm is intended for use with compatible integrated continuous glucose monitors (iCGM) and the twiist alternate controller enabled (ACE) insulin infusion pump to automatically increase, decrease, and suspend delivery of basal insulin based on iCGM readings and predicted glucose values. It can also recommend, and with the user’s confirmation, control the delivery of correction boluses when glucose values are predicted to exceed user configurable thresholds. The twiist Loop algorithm is intended for the management of type 1 diabetes mellitus in persons six years of age and greater. The twiist Loop algorithm is intended for single-patient use and requires a prescription.

The twiist Automated Insulin Delivery System includes a simple bolus calculator available when Loop is off. It is indicated for use for aiding the user in determining the bolus insulin dosage for management of diabetes mellitus based on consumed carbohydrates, operator entered blood glucose, insulin sensitivity, insulin to carbohydrate ratio, target glucose values, and current insulin on board.
CONTRAINDICATIONS

The twiist AID System is not intended for anyone unable or unwilling to:

  • Test blood glucose (BG) levels as recommended by their healthcare provider
  • Maintain sufficient diabetes self-care skills.
  • See their healthcare provider regularly
  • Demonstrate adequate carbohydrate-counting skills (preferred, not required).

The user must not:

  • Have difficulty seeing
  • Have difficulty hearing
  • Have deficient cognitive capabilities
  • Have physical impairments that would make operating the pump or iPhone difficult

Product not yet available outside of the U.S.
REFERENCES
1. Sequel Med Tech - twiist Automated Insulin Delivery (AID) System Powered by Tidepool User Guide.
2. Calculation based on a comparison of the following IFUs. The following reported 1 U/hr basal rate: Sequel Med Tech - twiist Automated Insulin Delivery (AID) System Powered by Tidepool User Guide; lnsulet - Omnipod 5 Automated Insulin Delivery System User Guide; Medtronic - MiniMed 780G system User Guide; Beta Bionics - iLet Bionic Pancreas System User Guide. The following reported 2 U/hr basal rate: Tandem Diabetes Care - t:slim X2 Insulin Pump User Guide; Tandem Diabetes Care - Tandem Mobi System User Guide.
3. lnsulet - Omnipod 5 Automated Insulin Delivery System User Guide.
4. Medtronic - MiniMed 780G system User Guide.
5. Beta Bionics - iLet Bionic Pancreas System User Guide.
6. Tandem Diabetes Care - t:slim X2 Insulin Pump User Guide.
7. Tandem Diabetes Care - Tandem Mobi System User Guide.
8. Lum JW, et al. A Real-World Prospective Study of the Safety and Effectiveness of the Loop Open Source Automated Insulin Delivery System. Diabetes Technol Ther. 2021;23(5):367-375.
9. Klonoff DC, et al. Time to Moderate and Severe Hyperglycemia and Ketonemia Following an Insulin Pump Occlusion. J Diabetes Sci Technol. 2024;18(6):1472-1479.
10. Wong JJ, et al. Psychosocial Effects of the Loop Open-Source Automated Insulin Delivery System. J Diabetes Sci Technol. 2023;17(6):1440-1447.
11. Butterfield RD, et al. Performance of a Continuous Subcutaneous Insulin Infusion (CSII) Pump With Acoustic Volume and Flow Sensing in Simulated High-Consequence Situations. IEEE Open J Eng Med Biol. 2024;5:593-599.

*The twiist™ Savings Program is available to individuals with a valid prescription and commercial insurance that covers twiist. Eligible participants can receive a Starter Kit for $0 and pay no more than $50 for Refill Kits. This offer is not valid for individuals enrolled in Medicare, Medicaid, or any other federal or state programs, or for cash-paying patients and non-covered claims. It is available only in the U.S. and is not valid in Puerto Rico, U.S. Territories, or where prohibited by law. While most commercially insured participants qualify for the $50 Refill Kit offer, those with high-deductible plans who haven't met their deductible may pay more than $50 per Refill Kit until their deductible is met. The maximum benefit is $200 per Refill Kit for covered claims. Terms are subject to change. Call us at 1-877-489-4478 or contact your insurance provider to confirm coverage.  

†Sequel is working on adhesive options for on-body wear. Alternative adhesive options are available through third-party providers.

‡Results obtained with the Loop algorithm using a non-twiist device.
Product for prescription only, for Important Safety Information please visit FreeStyleLibre.us
‍The sensor housing, FreeStyle, Libre, and related brand marks are marks of Abbott and used with permission.

The Eversense 365® Continuous Glucose Monitoring (CGM) System is indicated for continually measuring glucose levels for up to one year in people (18 years and older) with diabetes. For important safety information, see bit.ly/eversensesafety.

“twiist,” “iiSure,” and the twiist logo are licensed trademarks of Sequel Med Tech, LLC. “Tidepool” and the Tidepool logo are trademarks of Tidepool Project, a fully-qualified 501(c)(3) nonprofit organization. © 2026 Sequel Med Tech, LLC. All rights reserved.
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