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A different type
of insulin pump has arrived
Meet twiist™, an effective and more personalized Automated Insulin Delivery (AID) System for people with type 1 diabetes.1,3-7
Get updates and info about twiist
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Meet twiist™, an effective and more personalized Automated Insulin Delivery (AID) System for people with type 1 diabetes.1,3-7
Get updates and info about twiist
Sign Up

Designed to give you confidence and control over insulin delivery.

From unmatched personalization to unique features, see what makes twiist different from other insulin pumps.1,3-7
“It wasn’t until I tried twiist that I realized it wasn’t just a way to get insulin, it was a completely different lifestyle.”
Brooke
Living with type 1 diabetes since 2015
Adaptability: Customize it to your day
With unique features like pre-meal and activity presets, the widest glucose target range (87-180 mg/dL),1,3-7 and the ability to go back and change a carb entry or the time you ate, twiist adapts to your day with innovative technology that other insulin pumps or multiple daily injections don't offer.
Certainty: Precision with each dose
Using iiSure™ sound wave technology, twiist is the only pump that measures the actual volume of insulin delivered at every dose. That ensures the expected amount of insulin was delivered and helps detect insulin blockages up to 9x faster,2§ so you can take action sooner.
Effectiveness: Helps to keep you in range
twiist Loop is based on the proven Loop algorithm. An analysis of the Loop Observational Study revealed that users saw up to a 90% drop in severe lows.8‡ Fewer lows can mean more time in range and more confidence.
§Compared to other AID systems.
Don’t want to pull out your phone to give yourself insulin?
twiist is the only AID System that lets you discreetly give yourself insulin from a compatible smartwatch.

Ready to learn more about the new twiist AID System?

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INDICATIONS FOR USE
The twiist system is intended for the subcutaneous delivery of insulin, at set and variable rates, for the management of diabetes mellitus in persons requiring insulin, ages six and above. The pump is able to reliably and securely communicate with compatible, digitally connected devices, including automated insulin dosing software, to receive, execute, and confirm commands from these devices. The twiist system is intended for single patient, home use and requires a prescription.

The twiist Loop algorithm is intended for use with compatible integrated continuous glucose monitors (iCGM) and the twiist alternate controller enabled (ACE) insulin infusion pump to automatically increase, decrease, and suspend delivery of basal insulin based on iCGM readings and predicted glucose values. It can also recommend, and with the user’s confirmation, control the delivery of correction boluses when glucose values are predicted to exceed user configurable thresholds. The twiist Loop algorithm is intended for the management of type 1 diabetes mellitus in persons six years of age and greater. The twiist Loop algorithm is intended for single-patient use and requires a prescription.

The twiist Automated Insulin Delivery System includes a simple bolus calculator available when Loop is off. It is indicated for use for aiding the user in determining the bolus insulin dosage for management of diabetes mellitus based on consumed carbohydrates, operator entered blood glucose, insulin sensitivity, insulin to carbohydrate ratio, target glucose values, and current insulin on board.
CONTRAINDICATIONS

The twiist AID System is not intended for anyone unable or unwilling to:

  • Test blood glucose (BG) levels as recommended by their healthcare provider
  • Maintain sufficient diabetes self-care skills.
  • See their healthcare provider regularly
  • Demonstrate adequate carbohydrate-counting skills (preferred, not required).

The user must not:

  • Have difficulty seeing
  • Have difficulty hearing
  • Have deficient cognitive capabilities
  • Have physical impairments that would make operating the pump or iPhone difficult

Product not yet available outside of the U.S.
REFERENCES
1. Sequel Med Tech - twiist Automated Insulin Delivery (AID) System Powered by Tidepool User Guide.
2. Calculation based on a comparison of the following IFUs. The following reported 1 U/hr basal rate: Sequel Med Tech - twiist Automated Insulin Delivery (AID) System Powered by Tidepool User Guide; lnsulet - Omnipod 5 Automated Insulin Delivery System User Guide; Medtronic - MiniMed 780G system User Guide; Beta Bionics - iLet Bionic Pancreas System User Guide. The following reported 2 U/hr basal rate: Tandem Diabetes Care - t:slim X2 Insulin Pump User Guide; Tandem Diabetes Care - Tandem Mobi System User Guide.
3. lnsulet - Omnipod 5 Automated Insulin Delivery System User Guide.
4. Medtronic - MiniMed 780G system User Guide.
5. Beta Bionics - iLet Bionic Pancreas System User Guide.
6. Tandem Diabetes Care - t:slim X2 Insulin Pump User Guide.
7. Tandem Diabetes Care - Tandem Mobi System User Guide.
8. Lum JW, et al. A Real-World Prospective Study of the Safety and Effectiveness of the Loop Open Source Automated Insulin Delivery System. Diabetes Technol Ther. 2021;23(5):367-375.
9. Klonoff DC, et al. Time to Moderate and Severe Hyperglycemia and Ketonemia Following an Insulin Pump Occlusion. J Diabetes Sci Technol. 2024;18(6):1472-1479.
10. Wong JJ, et al. Psychosocial Effects of the Loop Open-Source Automated Insulin Delivery System. J Diabetes Sci Technol. 2023;17(6):1440-1447.
11. Butterfield RD, et al. Performance of a Continuous Subcutaneous Insulin Infusion (CSII) Pump With Acoustic Volume and Flow Sensing in Simulated High-Consequence Situations. IEEE Open J Eng Med Biol. 2024;5:593-599.

*The twiist™ Savings Program is available to individuals with a valid prescription and commercial insurance that covers twiist. Eligible participants can receive a Starter Kit for $0 and pay no more than $50 for Refill Kits. This offer is not valid for individuals enrolled in Medicare, Medicaid, or any other federal or state programs, or for cash-paying patients and non-covered claims. It is available only in the U.S. and is not valid in Puerto Rico, U.S. Territories, or where prohibited by law. While most commercially insured participants qualify for the $50 Refill Kit offer, those with high-deductible plans who haven't met their deductible may pay more than $50 per Refill Kit until their deductible is met. The maximum benefit is $200 per Refill Kit for covered claims. Terms are subject to change. Call us at 1-877-489-4478 or contact your insurance provider to confirm coverage.  

†Sequel is working on adhesive options for on-body wear. Alternative adhesive options are available through third-party providers.

‡Results obtained with the Loop algorithm using a non-twiist device.
Product for prescription only, for Important Safety Information please visit FreeStyleLibre.us
‍
The sensor housing, FreeStyle, Libre, and related brand marks are marks of Abbott and used with permission.

“twiist,” “iiSure,” and the twiist logo are licensed trademarks of Sequel Med Tech, LLC. “Tidepool” and the Tidepool logo are trademarks of Tidepool Project, a fully-qualified 501(c)(3) nonprofit organization.
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