Sequel™ is a company based in Manchester, N.H., maker of the twiist™ Automated Insulin Delivery (AID) System powered by Tidepool. The twiist AID System is designed for people aged 6 and up with type 1 diabetes. To learn more, visit sequelmedtech.com and twiist.com.

The twiist AID System is a user-friendly automated insulin delivery system designed to provide personalized type 1 diabetes management. At its core is the twiist Loop algorithm, which is based on Loop, an algorithm developed by people with diabetes for people with diabetes. The twiist System offers customizable target glucose ranges from 87-180 mg/dL, advanced occlusion detection, and control from your iPhone and connected Apple Watch. With flexible wear options, 300-unit capacity and a small, discreet form factor, twiist is built for people with diabetes who want to customize their diabetes management to meet their unique needs.

The twiist Pump is small but mighty! It weighs less than 2oz, and holds 300 units of insulin, making it the smallest available insulin pump with such a large capacity^1,3-7. It can detect blockages up to 9x faster than other AID systems²

It is called twiist™ because you twist it to open the device (kind of like an Oreo cookie)

The ii in twiist stands for intelligent insulin.

The twiist™ Pump is proudly manufactured in the United States.

The patented iiSure Technology is an innovative technology that directly measures the volume of insulin delivered and includes 4 checkpoints along the way to help ensure that users get the insulin they expect. This technology also alerts users to blockages (occlusions) up to nine times faster than other insulin pump systems².

• twiist™ has a wider Correction Range than any other commercially available system (as low as 87 mg/dL and as high as 180 mg/dL).^1,3-7
• The Correction Range settings can be programmed with up to 48 different segments.
• No other system has a "Premeal Preset" that can be used to target a lower glucose as a person is preparing to eat – this allows for some additional insulin to work prior to eating
• Workout Preset range (as low as 87 mg/dL and as high as 250 mg/dL)
• Emojis to represent carb absorption time (user can see "carbs on board")
• Users may retroactively add or edit the carbohydrate amount entered
• Shows the user the glucose prediction graph that updates every 5 minutes as the algorithm makes basal insulin adjustments.

Tidepool is a non-profit organization focused on diabetes. This technology is community-driven, designed by and for people living with diabetes, and offers extensive customizable options to truly personalize diabetes management. Sequel partnered with Tidepool because of their commitment to empowering the diabetes community. For further details about Tidepool, please visit www.tidepool.org.

Yes! We are looking to fill many roles as we expand our U.S. launch. Please visit our website here: https://sequelmedtech.com/careers/ to see if a position is right for you!

We tried capitalizing the ‘T’ in twiist, but it just didn’t feel right—like wearing socks with sandals. Plus, lowercase ‘t’ keeps things small, sleek, and stylish… just like our pump!

The twiist™ AID System is running a modified version of the Tidepool Loop algorithm based on the Open Source/DIY version of Loop. twiist Loop has been cleared by the FDA.

You can share your twiist AID System data with your healthcare provider using the Tidepool Data Platform linked through your My twiist Portal account.

The twiist™ App requires an iPhone with a minimum operating system version of iOS 18. An Android version is currently in development.  The twiist App is also compatible with all released versions of the Apple Watch running Apple Watch OS 11 and newer – This optional component provides a discreet way to view your sensor glucose and insulin information. When you choose to have Loop on, you can also enter carbs, deliver a bolus and more from your Apple watch.

twiist™ AID System powered by Tidepool is designed to help manage your diabetes by adjusting your basal insulin based on a 6-hour prediction of your CGM glucose levels. You can set your correction range between 87-180 mg/dL, and the system will work to keep you in that range. For meals, simply enter the total grams of carbs into the bolus calculator, and it will help you calculate the right insulin dose. You can also give correction doses whenever needed. Plus, you can bolus right from your connected Apple Watch, your iphone, or from the pump itself.

The twiist™ Starter Kit comes with 4 rechargeable batteries and 2 chargers, this helps ensure you always have a battery charged and ready to go.

A fully charged pump battery will power the pump for 3 days (72 hours) and should be swapped each time a cassette (reservoir) change is completed.

The twiist™ Pump offers a variety of flexible wear options. It can be secured to a belt or clothing using the provided pump clip, we are designing adhesive patches that will allow it to be worn on body, or it can also be discreetly placed in a clothing pocket like a traditional tubed insulin pump.

Yes, you can use the Bolus button to bolus directly from the pump itself, even when you are not close to your phone.

The Correction Range can be set as low as 87 mg/dL (4.8 mmol/L) and as high as 180 mg/dL (10 mmol/L). It can be set to different values at different times of the day to meet your unique needs. Your Correction Range should be set with the direction of your healthcare provider.

twiist features iiSure™ Technology, which provides the fastest blockage detection - up to nine times faster than other AID systems². This gives you more time to make necessary adjustments to potentially prevent high glucose levels related to infusion set failure⁹.

The twiist Pump can hold up to 300 units of insulin.

We are pleased to share that we have partnered with Tidepool. twiist™ users and their healthcare providers have access to their reports in the Tidepool Data Management System.

The twiist™ AID System uses the twiist Loop algorithm which uses a 6-hour prediction based on your personal settings, your current glucose value, how much insulin you have on board, the past 30 minutes of blood glucose changes, and your carbohydrate information to adjust every 5 minutes to help keep you in your Target Range. It does not learn with time and only adapts based on the parameters described above.

The twiist™ AID System uses your preferences for whether closed loop mode is on or off. It will keep "looping" if you have CGM values available when Loop is “on”. Otherwise. it will return to your pre-programmed basal settings until your CGM values are available.

Yes, you can always switch the twiist™ AID System to Loop Off whenever you choose.

Yes, we know how important the caregiver's role is. We have designed the twiist insiight App for them to remotely see  key diabetes management data updates, including glucose levels, active insulin, and carbohydrate entries from the twiist AID System. Please note that the insiight App is not intended to be a replacement for the information displayed by the twiist System App and should not inform dosing decisions.

twiist offers unmatched personalization, allowing individuals to set their personal glucose target within the widest Correction Range of any available AID system (87 mg/dL to 180 mg/dL)^1,3-7. It also features next-level delivery technology, 24/7 world-class product support, and unique features like food emoji libraries and Pre-Meal Preset.

When the twiist pump and app are not in communication or your iPhone is powered off, the following functionality is still available:

When Loop is on, the twiist AID System will continue to adjust basal delivery based on information from your CGM.
When Loop is off, the twiist AID System will continue to deliver the programmed basal insulin.
One-button boluses can still be delivered (when enabled in Settings).
Alarm, urgent alert, CGM alert, CGM urgent alert, and alert settings are saved in a manner that is unaffected by power loss.

twiist is now available nationwide! Please visit https://www.twiist.com/discover-twiist to learn more about twiist and get connected with us.

To make the twiist™ AID System the best access experience for providers and people with diabetes, we are focusing on making it available exclusively through the pharmacy channel. We are not currently planning to make the twiist AID System available through the DME channel.

Most people pay $0 the 1st month for the twiist™ AID System and no more than $50 each month thereafter.*

We're are currently focused on the U.S.. Our ultimate goal is to make this innovative technology available to people worldwide. We're already taking steps to expand twiist availability beyond the U.S. Regulatory approval and reimbursement vary by region; therefore, we don't have a timeline for international availability yet. Stay tuned by following our page or visiting twiist.com for updates!

Please follow this link www.twiist.com/discover-twiist to learn more about twiist, what to expect while getting started, and how to connect with a twiist representative!

We continue to work to gain access across all types of insurance including different Medicare and Medicaid plans. Please reach out to your specific plan for coverage.

There is no contract obligation. People living with type 1 diabetes can try twiist without the four-year commitment required by many traditional AID systems, but with the flexibility to manage their diabetes on their terms. Additionally, if you are using an AID system that is in existing warranty, you do not need to wait until your current warranty is up to try twiist.

People with type 1 diabetes with an AID system in existing warranty can still try twiist through the pharmacy channel. They do not need to wait until their current warranty is up to try twiist.

The twiist™ AID System is cleared for people 6 and up with type 1 diabetes, with a prescription

The twiist™ AID System is currently cleared for use with the following fast-acting U-100 insulin: Humalog® and Novolog®.

Switching from multiple daily injections (MDI) to the twiist™ AID System could be a game-changer! With MDI, you're used to giving yourself insulin injections multiple times a day. The twiist™ AID System, powered by Tidepool, means no more injections! It automates insulin delivery for you, adjusting your basal insulin based on your real-time sensor data to help keep your glucose levels within your correction range.

If you have any more questions or need support with the transition, feel free to ask!

Our team is working towards having Android compatibility available in the future.

Currently, the system is designed to work with compatible iPhones only. We are working towards Android phone compatibility in the future.

Sequel™ offers training by Certified twiist™ Trainers, ensuring you get the support you need to use the twiist AID System confidently and effectively.

We have 24/7 live product support with representatives fluent in both English and Spanish. In addition, you’ll have access to Diabetes Educators and a dedicated Customer Care Team to support you throughout your journey using the twiist™ AID System.

Pre-training support:
Our team will connect with you to determine eligibility, ensure you have everything you need and schedule your new start training

Post-training support:
Our Customer Care team is available for whatever you need following your training. We will reach out to you directly to provide follow up support on safe and effective use of the device post new start training and will provide additional refill support as well.

Ongoing support:
Our Product Support team is available 24/7 to help with any troubleshooting related to your twiist Pump, twiist App or other system components

The setup is similar to traditional insulin pumps. Healthcare providers (HCPs) assist people with diabetes with determining their Correction Range and other insulin pump settings.
People with diabetes need only enter their carbohydrates and emojis representing the type of food, and maintain the system

Unlike traditional Open Source or DIY Loop, you are not required to build the twiist™ App yourself. twiist Loop is provided as part of the twiist AID system.

twiist is compatible with both the FreeStyle Libre 3 Plus sensor and the Eversense 365!

Yes, we will be looking to add additional CGM partners in the future in order to make advanced diabetes management more accessible and flexible for people living with diabetes. We are on a mission to improve the lives of people with diabetes and give them choice in how they manage their diabetes. Having multiple CGM options, so people can select the one that is best for them, is one of the ways we will bring this to life.