Introducing a breakthrough

The twiist™ Automated Insulin Delivery (AID) System powered by Tidepool is the next generation of type 1 diabetes management.

What is twiist?

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Get to know twiist

twiist is an automated insulin delivery (AID) system designed to help people with type 1 diabetes manage their blood sugar levels.

It’s a small, wearable insulin pump that works with an app on your iPhone to automatically adjust insulin delivery based on your glucose levels. At its core is twiist Loop, a smart technology that helps keep glucose levels in range by predicting where they're headed and making adjustments.¹

Some key features:
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‍Full phone control – You can manage everything from your iPhone and even bolus from your connected Apple Watch.¹
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‍Flexible wear options – You can wear twiist 3 different ways-secured to a belt or clothing using the pump clip, we are working on adhesive patches that will allow it to be worn on body, or it can be discreetly tucked away.¹
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‍Widest glucose range – Allows you to customize you Correction Range anywhere between 87 and 180 mg/dL.^1,3-7
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‍Faster blockage detection – Can quickly detect insulin flow issues and alert you.²

In short, twiist is designed for people who want personalization, flexibility, and a discreet way to manage their diabetes.

Woman resting during exercise and checking her apple watch

Leave yesterday’s diabetes care behind, and imagine a new era of personalized diabetes management.

Imagine life without

A one-size-fits-all approach

Restrictive glucose targets

Long-term commitments

Imagine life with twiist

Unmatched personalization — select the features and wear options that align with your unique approach to diabetes management¹

twiist Loop technology —twiist Loop is based on the original diabetes community-developed Loop and allows you to set one or many target ranges throughout the day anywhere from 87–180 mg/dL¹

Planned easy pharmacy access — $0 to start and $50 per month ongoing* - no 4 year contracts or commitments

INDICATIONS FOR USE¹

The twiist system is intended for the subcutaneous delivery of insulin, at set and variable rates, for the management of diabetes mellitus in persons requiring insulin, ages six and above. The pump is able to reliably and securely communicate with compatible, digitally connected devices, including automated insulin dosing software, to receive, execute, and confirm commands from these devices. The twiist system is intended for single patient, home use and requires a prescription.

The twiist Loop algorithm, is intended for use with compatible integrated continuous glucose monitors (iCGM) and the twiist alternate controller enabled (ACE) insulin infusion pump to automatically increase, decrease, and suspend delivery of basal insulin based on iCGM readings and predicted glucose values. It can also recommend, and with the user’s confirmation, deliver correction boluses when glucose values are predicted to exceed user configurable thresholds. The twiist Loop algorithm is intended for the management of type 1 diabetes mellitus in persons six years of age and greater, and is intended for single-patient use.The twiist automated insulin delivery system is for prescription use only .

The twiist automated insulin delivery system simple bolus calculator, available when Loop is off, is indicated for use for aiding the user in determining the bolus insulin dosage for management of diabetes mellitus based on consumed carbohydrates, operator-entered blood glucose, insulin sensitivity, carbohydrate ratio, correction range, and current active insulin.

REFERENCES

1. The twiist Automated Insulin Delivery (AID) System Powered by Tidepool User Guide, Sequel Med Tech: DKPI-09233-001-EN 1.7 2024-10-21 2.Calculation based on a comparison of the following IFUs. The following reported 1 U/hr basal rate: The twiist Automated Insulin Delivery (AID) System Powered by Tidepool User Guide, Sequel Med Tech (DKPI-09233-001-EN 1.7 2024-10-21). Omnipod 5 Technical User Guide (PT-000941-AW Rev07 10/24), MiniMed 780G System User Guide (M036461C001_2 2023-02-24). iLet Bionic Pancreas System User Guide (LA000081_E 3-19-24). The following reported 2 U/hr basal rate: t:slim X2 Insulin Pump User Guide (AW-1011648_B 2023-Nov-09), Tandem Mobi System User Guide (AW-1012691_A 2023-Dec-07.) 3. Omnipod 5 Technical User Guide. Insulet Corporation; PT-000941-AW Rev. 07 10/24 4.MiniMed 780G with the Guardian 4 Sensor System User Guide, Medtronic:M036461C001_2 2023-02-24 5. iLet Bionic PancreasSystem User Guide, Beta Bionics: LA000081_E 6. t:slim X2 Insulin Pump with Control-IQ TechnologyUser Guide, Tandem Diabetes Care: AW-1011648_B 2023-Nov-09 7. Tandem MobiSystem, Tandem Diabetes Care: AW-1012691_A 2023-Dec-07 8.. Lum JW, et al. A Real-World Prospective Study of the Safety and Effectiveness of the Loop Open Source Automated Insulin Delivery System. Diabetes Technol Ther 2021;23(5):367–75. 9.Data on file. Sequel Med Tech, LLC. 2023. 10. Wong JJ, et al. PsychosocialEffects of the Loop Open-Source Automated Insulin Delivery System. J DiabetesSci Technol 2023; 17(6):1440–7. 11. Butterfield RD, et al. Performance of aContinuous Subcutaneous Insulin Infusion (CSII) Pump with Acoustic Volume andFlow Sensing in Simulated High-Consequence Situations. IEEE Open J Eng Med Biol2024;PP(99):1–7.

*To be eligible for the twiist Savings Program, participants must have commercial insurance and not be enrolled in programs that pay for prescriptions in whole or in part by Medicare, Medicaid or any other federal or state programs. It is only valid in the United States, and not valid for cash-paying participants, in Puerto Rico or U.S. Territories, or where prohibited by law. The pay no more than $50 offer is applicable to most participants on commercial insurance, based on copay and coinsurance averages across all tiered cost sharing plan designs, but may not be applicable to participants on high-deductible plans who have not yet reached their deductible. Max benefit per month for covered claims is $200.

† Adhesive options for on body wear are currently being developed.

‡Results obtained with the Loop algorithm using a non-twiist device

CONTRAINDICATIONS¹

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The twiist AID System is not intended for anyone unable or unwilling to:

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Test blood glucose (BG) levels as recommended by their healthcare provider
Maintain sufficient diabetes selfcare skills.
See their healthcare provider regularly
Demonstrate adequate carbohydrate-counting skills (preferred, not required).

The user must not:

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Have difficulty seeing
Have difficulty hearing
Have deficient cognitive capabilities
Have physical impairments that would make operating the pump or iPhone difficult

Product not yet available outside of the U.S.

For full FreeStyle Libre 3 Plus sensor safety information, please visit https://www.freestyle.abbott/us-en/safety-information.html.
The sensor housing, FreeStyle, Libre, and related brand marks are marks of Abbott and used with permission.

“twiist,” “iiSure,” and the twiist logo are licensed trademarks of Sequel Med Tech, LLC. “Tidepool” and the Tidepool logo are trademarks of Tidepool Project, a fully-qualified 501(c)(3) nonprofit organization.
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